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Linezolid is an antibiotic used for the treatment of infections caused by Gram-positive bacteria that are resistant to other antibiotics. When given for short periods, linezolid is a relatively safe antibiotic. As a protein synthesis inhibitor, linezolid works by suppressing bacterial protein production. Linezolid was discovered in the mid s, and was approved for commercial use in The main use of linezolid is the treatment of severe infections caused by aerobic Gram-positive bacteria that are resistant to other antibiotics; it should not be used against bacteria that are sensitive to drugs with a narrower spectrum of activity, such as penicillins and cephalosporins. In the United States, the indications for linezolid use approved by the U. Linezolid appears to be as safe and effective for use in children and newborns as it is in adults. A large meta-analysis of randomized controlled trials found linezolid to be more effective than glycopeptide antibiotics such as vancomycin and teicoplanin and beta-lactam antibiotics in the treatment of skin and soft tissue infections SSTIs caused by Gram-positive bacteria, and smaller studies appear to confirm its superiority over teicoplanin in the treatment of all serious Gram-positive infections. In the treatment of diabetic foot infections, linezolid appears to be cheaper and more effective than vancomycin. Some authors have recommended that combinations of cheaper or more cost-effective drugs such as co-trimoxazole with rifampicin or clindamycin be tried before linezolid in the treatment of SSTIs when susceptibility of the causative organism allows it.
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Risks involved outweigh potential benefits. Close monitoring of blood pressure is necessary.
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Linezolid is used to treat infections, including pneumonia, and infections of the skin. It works by stopping the growth of bacteria. Antibiotics such as linezolid will not work for colds, flu, and other viral infections.
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Licensed by Catalog No. S Synonyms : PNU Linezolid is a synthetic antibiotic used for the treatment of serious infections.
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Methicillin-resistant Staphylococcus aureus MRSA nosocomial pneumonia NP is associated with higher resource utilization, increased hospital stays, and mortality. The model is a decision-analytic analysis in which a MRSA-confirmed patient is simulated to utilize one of the treatments, using data from a clinical trial.
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