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Ezetimibe is a non-statin lipid-lowering medication that inhibits absorption of dietary cholesterol by blocking the Niemann-Pick C1-Like 1 protein NPC1L1. Moreover, based on a recent unique analysis of the IMPROVE-IT trial, ezetimibe reduced additional and total cardiovascular events over the course of the study, not only the first occurring event as trials are traditionally designed to assess. The expert panel stated that non-statin therapies were an important consideration in high-risk patients when a less-than-anticipated LDL-C lowering was observed. How low can we go with LDL-C? Is ezetimibe safe? The analysis addresses the fact that patients with a nonfatal, first cardiovascular event are at risk of developing additional events.

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