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Comments:
Skeletal muscle relaxants are widely used in treating musculoskeletal conditions. However, evidence of their effectiveness consists mainly of studies with poor methodologic design. In addition, these drugs have not been proven to be superior to or nonsteroidal anti-inflammatory drugs for low back pain.
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Tizanidine is a central alpha-2 adrenergic receptor agonist and was first considered as a viable treatment for TN in a double-blind study comparing it to carbamazepine. From: Nerves and Nerve Injuries, Jennifer A.
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