This was the subject of a consultation letter dated 14 May Additional subsidy by endorsement for a patient who cannot swallow whole tablets and in whom ibuprofen oral liquid is ineffective or not tolerated, and the prescription is endorsed accordingly. Note: Subsidy for patients with existing approvals prior to 1 September Approvals valid without further renewal unless notified. No new approvals will be granted from 1 September All consultation responses were considered in their entirety in making a decision on the proposed changes.
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No overall differences in efficacy or safety were observed between these patients and younger patients, but greater sensitivity of some older individuals cannot be ruled out. As there is evidence that alendronate is not metabolized or excreted in the bile, no studies were conducted in patients with hepatic impairment. Hypocalcemia, hypophosphatemia, and upper gastrointestinal adverse events, such as upset stomach, heartburn, esophagitis, gastritis, or ulcer, may result from oral overdosage.
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