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Although still controversially discussed, carbamazepine was found to offer beneficial effects in the treatment of schizophrenia. Nonetheless, data on these effects are limited by small sample sizes or poor design of most of the respective studies. Furthermore, the complex pharmacological interactions of new atypical neuroleptics with carbamazepine underline the necessity of alternative strategies in adjuvant treatment of schizophrenia as well as in combined treatment of bipolar disorders with mood stabilizers and neuroleptics. Oxcarbazepine OXC is a new anticonvulsant drug that acts as a pro-drug for the monohydroxy metabolite MHD, https://health.usnews.com an active metabolite also of carbamazepine that is suggested to be responsible for most of its therapeutic actions. Therefore, the pharmacological action of OXC is very well comparable to carbamazepine whilst there are fewer unwanted side effects of OXC regarding eg. This is an explorative controlled study with Oxcarbazepine OXC as an adjunct in the acute treatment of schizophrenia. The primary hypothesis of this study is that adjunctive treatment with OXC yields at least comparable efficacy regarding antipsychotic actions with lower doses of neuroleptics and consequently substantially fewer adverse events. A randomised controlled, double blind study is intended. After the initial lead-in of OXC within 7 days allowing as comedication, treatment with olanzapine will be started. Based on biometric calculations, a drop out adjusted sample size of inpatients will be necessary.
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Jakob (taken for 3 to 4 years) 17.01.2017
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The score line is only to facilitate breaking for ease of swallowing and not to divide into equal doses. Trileptal is indicated for the treatment of partial seizures with or without secondarily generalised tonic-clonic seizures.
Angelika (taken for 3 to 6 years) 30.08.2019
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What is Trileptal? Trileptal is a medication known as an anticonvulsant that is used to treat seizures.
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The authors suggest that the decreased morbidity due to PHN more than adequately offsets the cost of large-scale immunization of individuals aged 60 years or older. Involved in the presentation of peptide antigens to the immune system.
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