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Topiramate is used as initial monotherapy or as adjunctive therapy in the management of seizure disorders. Efficacy of the drug in the management of seizure disorders was evaluated using topiramate immediate-release tablets. Topiramate is used as initial monotherapy in the management of partial seizures or primary generalized tonic-clonic seizures in adults and pediatric patients 2 years of age and older. Safety and efficacy of topiramate monotherapy in patients who previously received a regimen of other anticonvulsant agents have not been established in controlled trials. Safety and efficacy of topiramate as initial monotherapy were established in a randomized, double-blind study in patients age range: years with epilepsy who had 1 or 2 well-documented seizures within 3 months prior to enrollment and were not receiving anticonvulsant therapy at the time of randomization.
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