Imipramine is a tricyclic antidepressant and modulates GR transcriptional activity by acting as a partial GR agonist, while mefipristone RU, a potent progesterone antagonist used for medical termination of intrauterine pregnancies, also inhibits GR activity by acting as a potent GR antagonist. From: Handbook of Neuroendocrinology, Browman, G. Imipramine Figure 3 is a TCA. Imipramine is comprised of a tricyclic nucleus including two phenyl rings and a central cycloheptadien ring. Carl P. Log on to ExpertConsult.
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