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To determine, in men with erectile dysfunction ED, the extent of improvement in erection hardness and in the rate of successful sexual intercourse SSI during the final intercourse attempt using sildenafil 50 mg compared with the subsequent initial attempt after a dose increase to mg. This post hoc analysis used data from two randomized, double-blind, placebo-controlled studies of flexible-dose sildenafil for the treatment of men with ED, who were given sildenafil 50 mg or matching placebo, to be taken as needed before sexual intercourse. Between the final 50 mg sildenafil dose and the initial mg sildenafil dose, the outcomes improved and significantly so in the larger study. The improved efficacy with sildenafil mg versus 50 mg, which occurs rapidly, suggests that patients should be encouraged to use mg if they are unable to achieve completely hard and fully rigid erections or SSI with the 50 mg dose. Quality of life is decreased by ED, which is associated with low self-esteem, depression, and anxiety. The objective of this study was to determine the extent of improvement in erection hardness and in the rate of SSI during the final attempt at https://www.cub.com sexual intercourse when using a dose of 50 mg compared with the results for the subsequent initial attempt at sexual intercourse after a dose increase to mg. These studies were selected from the overall sildenafil clinical trials database of 74 double-blind, placebo-controlled trials because both administered a flexible-dose regimen of sildenafil and assessed EHS and SSI.

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