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Atomoxetine is a selective norepinephrine NE reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder ADHD. Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities psychological, educational, cognitive behaviour therapy, https://www.wrcbtv.com etc to improve developmentally inappropriate symptoms associated with ADHD including distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. Although the underlying pathophysiology that causes ADHD remains unclear, evidence suggests that dysregulation in noradrenergic and dopaminergic pathways plays a critical role in suboptimal executive functioning within prefrontal regions of the brain, which are involved in attention and memory. Many contain a blackbox warning stating that CNS stimulants, including methylphenidate-containing products and amphetamines, have a high potential for abuse and dependence. In particular, increased dopamine in key areas caused by these stimulant medications is associated with their reinforcing and addictive properties, and even amplifies the potency and reinforcing effects of other drugs of abuse such as amphetamines, making ADHD sufferers more susceptible to their addictive effects. A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Atomoxetine is indicated for the treatment of attention deficit hyperactivity disorder ADHD in children and adults. Due to atomoxetine's noradrenergic activity, it also has effects on the cardiovascular system such as increased blood pressure and tachycardia. Atomoxetine should be used with caution in patients whose underlying medical conditions could be worsened by increases in blood pressure or heart rate such as certain patients with hypertension, tachycardia, or cardiovascular or cerebrovascular disease. Patients who develop symptoms such as exertional chest pain, unexplained syncope, or other symptoms suggestive of cardiac disease during atomoxetine treatment should undergo a prompt cardiac evaluation.
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Common side effects include abdominal pain, loss of appetite, nausea, feeling tired, and dizziness. Atomoxetine was approved for medical use in the United States in Atomoxetine is approved for use in children, adolescents, and adults. While its efficacy may be less than that of stimulant medications, there is some evidence that it may be used in combination with stimulants. The initial therapeutic effects of atomoxetine usually take 2—4 weeks to become apparent.
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The pharmacokinetic analysis was based on samples obtained from 88 subjects: the 58 paediatric subjects a total of samples in the current study, plus 30 adults a total of samples from the earlier study. Frequency distributions for age and body weight are presented in Figure 1. The individual desloratadine plasma concentration-time profiles for different age groups are illustrated in Figure 2.
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