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Montelukast is a leukotriene receptor antagonist that has demonstrated high affinity, binding to the leukotriene receptor. Inhibition of LTD4 and LTE4 reduces the bronchoconstriction and increased pulmonary vascular edema associated with an acute asthma attack. Montelukast is not used to treat an acute asthma attack. Montelukast is administered orally. Montelukast and its metabolites are excreted primarily in bile.
The PREVIA study was designed to investigate the role of montelukast, a leukotriene receptor antagonist, in the prevention of viral-induced asthma exacerbations in children aged 2 to 5 years with a history of intermittent asthma symptoms. Over 12 months of therapy, montelukast significantly reduced the rate of asthma exacerbations by The average rate of exacerbation episodes per patient was 1. Montelukast effectively reduced asthma exacerbations in 2- to 5-year-old patients with intermittent asthma over 12 months of treatment and was generally well tolerated. Asthma generally begins and has its greatest prevalence in children younger than 5 years old 1 — 3. This age group often presents with intermittent symptoms i.
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