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Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. Doxepin commonly produces a E : Z racemic mixture. Doxepin was developed by and FDA approved in as an antidepressant.
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Low-dose doxepin is labeled for the treatment of insomnia characterized by difficulty maintaining sleep. The exact mechanism by which the medication exerts its sleep maintenance effect is unknown, but is thought to be antagonism of histamine H 1 receptors.
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