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Common side effects include sleepiness, constipation, weight gain, and dry mouth. Quetiapine was developed in and approved for medical use in the United States in Quetiapine is primarily used to treat schizophrenia or bipolar disorder. In a comparison of 15 antipsychotics in effectiveness in treating schizophrenia, quetiapine demonstrated standard effectiveness. It is debatable whether, as a class, typical or atypical antipsychotics are more effective. In those with bipolar disorder, quetiapine is used to treat depressive episodes; acute manic episodes associated with bipolar I disorder as either monotherapy or adjunct therapy to lithium ; valproate or lamotrigine ; and maintenance treatment of bipolar I disorder as adjunct therapy to lithium or divalproex. Quetiapine is effective when used by itself and when used along with other medications in major depressive disorder MDD. Quetiapine does not decrease agitation among people with Alzheimer's.
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Either immediate-release or extended-release tablets may be given; dosage titrated upward over 4 days. Generally, in maintenance phase, patients continue to receive same dosage on which they were stabilized. Drug reaction with eosinophilia and systemic symptoms DRESS, falls, nocturnal enuresis, retrograde amnesia, syndrome of inappropriate antidiuretic hormone secretion SIADH, Stevens-Johnson syndrome SJS, toxic epidermal necrolysis TEN, decreased platelet count, serious liver reactions including hepatitis, liver necrosis, and hepatic failure, agranulocytosis, intestinal obstruction, ileus, colon ischemia, urinary retention, sleep apnea, and acute generalized exanthematous pustulosis AGEP. Increased risk of hyperglycemia and diabetes; in some cases, hyperglycemia concomitant with use of atypical antipsychotics has been associated with ketoacidosis, hyperosmolar coma, or death; monitor blood glucose of high-risk patients for symptoms of hyperglycemia including polydipsia, polyuria, polyphagia, and weakness; monitor glucose regularly in patients with diabetes or at risk for diabetes. Can elevate prolactin levels, and elevation can persist during chronic administration; hyperprolactinemia may suppress hypothalamic GnRH, resulting in reduced pituitary gonadotropin secretion; this, in turn, may inhibit reproductive function by impairing gonadal steroidogenesis in both female and male patients.
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