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Risperidone Risperdal is a mixed serotonin-dopamine antagonist labeled to treat schizophrenia and mania associated with bipolar I disorder in adults. It was recently approved for the treatment of irritability associated with autistic disorder in children five to 17 years of age. Off-label uses include treatment of other symptoms of autistic disorder, including aggression, self-injurious behavior, hyperactivity, and inattention. Extrapyramidal symptoms e. Food and Drug https://www.capbluecross.com Administration pregnancy category C. Most patients 50 to 75 percent will experience fatigue or drowsiness with risperidone. Ten to 25 percent of patients exhibit weight gain, with mean increases of 5 lb, 15 oz to 6 lb, 8 oz 2.
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Patients experiencing a first psychotic episode have high rates of extrapyramidal symptoms EPSs when treated with the doses of neuroleptics used in multiepisode or chronic schizophrenia. There is some evidence that lower doses may be equally, if not more, effective but less toxic in this population. Reports of EPS remained low, and there were no dystonic reactions. Evidence increasingly suggests that early intervention with antipsychotic medications has a positive effect on treatment response and outcomes in patients with schizophrenia. In contrast, a delay in initiation of antipsychotic treatment is associated with slower and less significant symptomatic recovery and poorer overall outcomes. The first five years after onset appears to be the critical window where the greatest functional decline associated with the illness occurs, indicating that initiation of treatment during this period may be particularly beneficial. The progressive functional decline during this period may reflect, among other factors, alterations in brain structure and volume associated with increasing duration of illness in schizophrenia. Early intervention with antipsychotic medications and psychosocial care has been demonstrated to modify these outcomes over time. As well as altering neurotransmitter activity, certain antipsychotic agents have a potentially neuroprotective effect.
Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical pathways, respectively. Risperidone binds with a very high affinity to 5-HT2A receptors, approximately fold greater than the drug's binding affinity to D2 receptors, 13, 3 and carries lesser activity at several off-targets which may responsible for some of its undesirable effects. A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Risperidone is indicated for the treatment of schizophrenia and irritability associated with autistic disorder. Risperidone is additionally indicated in Canada for the short-term symptomatic management of aggression or psychotic symptoms in patients with severe dementia of the Alzheimer type unresponsive to nonpharmacological approaches. Risperidone is also used off-label for a number of conditions including as an adjunct to antidepressants in treatment-resistant depression.
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Risperdal risperidone is a temporal of the adjusted antipsychotics drug class and is also used for Asperger Lebanese, Autism, Bipolar Disorder, and others. Otoscopes are for many paying customers only and are not indicated with insurance companies.
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