Zyvox mg film-coated tablets 2. Qualitative and quantitative composition Each tablet contains mg linezolid. For the full list of excipients, see section 6. Clinical particulars 4. Linezolid is not active against infections caused by Gram negative pathogens. Specific therapy against Gram negative organisms must be initiated concomitantly if a Gram negative pathogen is documented or suspected.

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Linezolid has been in general use in the UK since Although toxicity, particularly haematological and neurological, has been an issue, linezolid has proved to be an effective alternative to glycopeptides in the treatment of Gram-positive infections. Linezolid was first licensed in and is currently approved for use in the UK to treat documented complicated skin and soft tissue infections SSTIs and pneumonia caused by susceptible Gram-positive bacteria. In the years since it became available, the use of linezolid has been widened to include the treatment of other difficult infections. This article focuses on the safety and efficacy of linezolid in these clinical settings. In particular, this article will discuss the use of this agent in patients who have pre-existing conditions or who are at risk for some of the recognized adverse effects of linezolid.