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Alexander (taken for 1 to 5 years) 19.01.2016
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This statement is included on the product's bottle label. The cumulative frequency of nephrolithiasis events increases with increasing exposure to CRIXIVAN; however, the risk over time remains relatively constant.
Egon (taken for 2 to 7 years) 17.07.2018
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In elderly patients, a slight reduction in renal clearance of sulfamethoxazole but not trimethoprim has been observed. At doses in excess of recommended human therapeutic dose, trimethoprim and sulfamethoxazole have been reported to cause cleft palate and other foetal abnormalities in rats, findings typical of a folate antagonist.
Effects with trimethoprim were preventable by administration of dietary folate.
Paul (taken for 2 to 4 years) 05.04.2017
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