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Tacrolimus is the primary immunosuppressive drug used in kidney transplant patients. All other drugs were maintained as per normal practice. There were nine infectious episodes treated satisfactorily with proper therapies. Tacrolimus is the primary immunosuppressant used in solid organ transplant patients. Generic products must document comparable bioavailability with their innovator counterpart as dictated by regulatory agencies, like FDA or EMA. Observations in normal healthy volunteers may not necessarily represent what is likely to happen in solid organ transplant recipients, possibly because they do have comorbidities, such as gastrointestinal motility disorders or use of concomitant medications that could affect pharmacokinetics of drug being studied. Alloway et al. The identity of the patients was guarded during collection and analysis of research data. We included all adult patients with more than three months after transplantation, with stable preswitch tacrolimus dose and blood levels for at least 4 weeks and at least three blood tacrolimus and serum creatinine blood levels before and after the switch.

A model was developed in Microsoft Excel to estimate costs associated with immunosuppressive medications and retransplantation. Over a 3-year time horizon, the numbers needed to treat with PR tacrolimus relative to IR tacrolimus were 14 to avoid one graft loss and 18 to avoid one death. Liver transplantation is a highly effective treatment option for patients with end-stage liver disease, and as of there were approximately patients with a functioning liver transplant in the UK Transplant Registry, up from in. While these improvements are a result of changes to many aspects of operative and peri-operative treatment implemented since the early transplants, improvements in post-transplant immunosuppression are generally considered to be the most important innovation. Several studies in liver transplant recipients have since confirmed that intra-patient variability is indeed reduced with PR tacrolimus relative to IR tacrolimus, and that the majority of patients prefer once-daily dosing over twice-daily dosing and are more adherent to the once-daily regimen.

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