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The efficacy of fenofibrate has been closely scrutinized in light of several studies that suggest that the lipid-modifying drug does little to reduce the risk of cardiovascular disease. Fibrates are a class of medications that target genes involved in lipid metabolism. The relevance of the earlier fibrates — clofibrate and gemfibrozil — to practice today is limited: clofibrate is no longer available in the U. Fenofibrate, the most commonly used medication in the class, was developed by Fournier Laboratories in the s. Fournier never marketed the drug in the U. In the U. Branded drugs are usually protected from competition for several years after approval, allowing their prices to be set at almost any level, in order to reward drug makers for their investment in the research and development process. Patent protection and data exclusivity work together to do this, as detailed in e-Appendix 1. Alternatively, generic drug makers can challenge remaining patents by making a special certification in their ANDAs e-Appendix 1. By law, this action requires the FDA to delay approval of the ANDAs by up to 30 months to give the legal system an opportunity to resolve the dispute, meaning that the branded drug maker remains protected from generic competition during this time.
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Fenofibrate and fenofibric acid are used as adjuncts to dietary therapy in the management of primary hypercholesterolemia and mixed dyslipidemia. The drugs also are used as adjuncts to dietary therapy in the management of severe hypertriglyceridemia. Drug therapy is not a substitute for, but an adjunct to, these nondrug therapies and measures, which should be continued when drug therapy is initiated. The effects of fenofibrate and fenofibric acid on cardiovascular morbidity and mortality or noncardiovascular mortality have not been established. Fenofibrate and fenofibric acid are used as adjuncts to dietary therapy to decrease elevated serum total and low-density lipoprotein LDL -cholesterol, triglyceride, and apolipoprotein B apo B concentrations, and to increase high-density-lipoprotein HDL -cholesterol concentrations in the management of primary hypercholesterolemia and mixed dyslipidemia, including heterozygous familial hypercholesterolemia and other causes of hypercholesterolemia.
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Claudia (taken for 1 to 4 years) 08.03.2018
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Okay, I was told that this stuff would work on tapeworms for my chickens, I just cant remember who on here told me. If you see that they seem pail headed, or loos weight and look droopy or see worms than you worm them. Dosage for Corid 9.
Alfred (taken for 3 to 7 years) 23.02.2017
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