A previously developed Markov state-transition model was used to estimate costs and benefits associated with initiating treatment with the different competing NSAIDs. Efficacy, gastrointestinal and cardiovascular safety, and resource use data were obtained from the literature. Data from different studies were synthesized and translated into direct costs and quality adjusted life years by means of a Bayesian comprehensive decision modeling approach. Over a year time horizon, etoricoxib is associated with about 0. At 1 year, naproxen is the most cost-saving strategy. Ankylosing spondylitis AS is a chronic inflammatory rheumatic disease that affects the axial skeleton, causing characteristics inflammatory back pain, which can lead to structural and functional impairments. In Europe, estimates of prevalence of ankylosing spondylitis vary by tenfold from 0.
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