Noncystic fibrosis bronchiectasis NCFB is characterized by airway expansion and recurrent acute exacerbations. To assess the efficacy of roxithromycin on airway inflammation and remodeling in patients with NCFB under steady state. At baseline and 6 months, the inflammatory markers such as interleukin- IL- 8, neutrophil elastase NE, matrix metalloproteinase- MMP 9, hyaluronidase HA, and type IV collagen in sputum were measured, along with the detection of dilated bronchus by throat computed tomography scan, and assessed the exacerbation. Forty-three patients completed the study. The neutrophil in the sputum was decreased in roxithromycin group compared with control. Airway thickness of dilated bronchus and exacerbation were reduced in roxithromycin group compared with the control all.
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