Stress, alcohol cues and dysregulated stress responses increase alcohol craving and relapse susceptibility, but few pharmacologic agents are known to decrease stress and cue-induced alcohol craving and associated stress dysregulation in humans. Here we report findings from a preliminary efficacy study of the alpha1 receptor antagonist, prazosin, in modulating these relapse-relevant factors in alcohol dependent AD individuals. Alcohol craving, anxiety and negative emotion, cardiovascular measures, plasma hypothalamic-pituitary-adrenal HPA; cortisol, ACTH were assessed repeatedly in each session. Prazosin appears efficacious in decreasing stress- and cue-induced alcohol craving and may normalize the stress dysregulation associated with early recovery from alcoholism. Despite this, there are currently only three medications approved by the US Food and Drug Administration FDA for the treatment of alcohol use disorders— acamprosate Campral, naltrexone Trexan and disulfiram Antabuse Ross and Peselow, The development of pharmacotherapies that target stress system dysregulation offers a promising new approach.
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Paroxetine was the first antidepressant approved in the United States for the treatment of panic disorder. Paroxetine has demonstrated efficacy for the treatment of social anxiety disorder in adults and children.
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