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Regardless of the receptor with which the bacteria interact, it has been observed that the cellular cholesterol present in the macrophage cell membrane is an essen- tial molecule for the internalization of the bacteria Gatfield It is believed that cellular cholesterol works as a direct anchorage point for the bacterium and stabilizes its interaction with the macrophage membrane. This structure de- rives from the plasma membrane and presents some cell surface receptors Russell, Hasan This inhibition depends on an active process induced by viable mycobacteria, since dead bacilli can be easily found in lysol compartments Armstrong, Armstrong In contrast, the role played by the reactive oxygen intermediates during infection has not been completely explained, though it is known that hydro- gen peroxide produced by macrophages activated by cytokines has a mycobacteri- cidal activity Walter Immune response against Mycobacterium tuberculosis receptors with which mycobacteria seem to interact.
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