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People who take nonsteroidal anti-inflammatory drugs NSAIDs other than aspirin such as naproxen may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. Do not take an NSAID such as naproxen if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. If you will be undergoing a coronary artery bypass graft CABG; a type of heart surgery, you should not take naproxen right before or right after the surgery. NSAIDs such as naproxen may cause ulcers, bleeding, or holes in the stomach or intestine.

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Naproxen is classified as a nonsteroidal anti-inflammatory dug NSAID and was initially approved for prescription use in and then for over-the-counter OTC use in A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Naproxen is indicated for the management of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and for the relief of mild to moderate pain. Naproxen is an established non-selective NSAID and is useful as an analgesic, anti-inflammatory and antipyretic. For instance, naproxen can adversely affect blood pressure control. Further, studies have found that the risk of upper gastrointestinal bleeding is on average four-fold higher for individuals taking NSAIDs.

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