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Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index. Azathiprine was granted FDA approval on 20 March
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The drug is also used to treat severe rheumatoid arthritis, psoriasis, ulcerative colitis, and Crohn's disease. Azathioprine is in class of drugs known as immunosuppressants.
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