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Vardanyan, V. Hruby, in Synthesis of Essential Drugs, Reduction of the nitro group in the resulting compound using tin dichloride in hydrochloric acid makes the desired dapsone. It has also been suggested to reduce the nitro group to an amino group, protect it with an acetyl protection, oxidize the sulfur atom to a sulfone using potassium dichromate, and then remove the protective acetyl group by hydrolysis. Reducing the nitro group in this compound with tin dichloride in hydrochloric acid along with the simultaneous hydrolysis of the acetyl group under the reaction conditions gives the desired dapsone.
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A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with https://www.consumeraffairs.com pyrimethamine in the treatment of malaria. From Martindale, The Extra Pharmacopoeia, 30th ed, p A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Dapsone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and antibiotic properties.
The dose of this medicine will be different for different patients. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, take it as soon as possible.
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Dapsone comes as a tablet to take by mouth. Dapsone usually is taken either once a day or three times a week.
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Oral dapsone is sometimes used for rheumatologic skin diseases. Dapsone is a sulfone that decreases inflammation in the skin, particularly when neutrophils a type of white blood cell cause the inflammation.
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It is an antibacterial drug for susceptible cases of leprosy. Inactive Ingredients: colloidal silicone dioxide, magnesium stearate, microcrystalline cellulose and pregelatinized starch.
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