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Lineu Prestes, ; ; sferraz usp. Key words: Chloramphenicol, Dissolution, Polymorphism. Chloramphenicol is a large spectrum antibiotic with antimicrobial activity. Its mechanism of action is based on the inhibition of protein synthesis; however, the resistance of gram-positive and gram-negative microorganisms in vivo is a clinical problem of increasing importance Kapusnik-Uner et al. Chloramphenicol is available for oral administration as chloramphenicol palmitate - a prodrug of chloramphenicol - developed with the objective of a more pleasent flavored derivative.
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Mark H. Wilcox, in Antibiotic and Chemotherapy Ninth Edition, The plasma concentration achieved is proportional to the dose administered. Pancreatic lipase is deficient in neonates and, because of poor hydrolysis, the palmitate should be avoided. Protein binding is reduced in cirrhotic patients and neonates, with correspondingly elevated concentrations of free drug. Extraintestinal translocation of colonic mucosa into regional lymph nodes and liver.
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