There are a few conditions other than prolactinomas that may be associated with hyperprolactinemia. As prolactin is regulated by dopamine, medications that interfere with this substance in the brain can cause elevated prolactin levels. Other drugs that can cause mild elevations of prolactin levels include estrogens and verapamil, a drug used to treat high blood pressure. An underactive thyroid or inadequate thyroid hormone replacement can also raise prolactin levels, as can kidney disease, pregnancy, stress, and chest trauma. If an elevated prolactin level is due to a medication, the level will usually return to normal days after the drug is stopped. It is not possible to determine the cause of an elevated prolactin from the blood level alone.
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