Doctors can now use the malaria drugs Plaquenil hydroxychloroquine and Aralen chloroquine to treat coronavirus. These drugs may stop the immune system from going overboard in its attack on the virus. Some patients with severe COVID have experienced organ failure and death, apparently because their immune system kept attacking long after the virus was defeated. Hydroxychloroquine helps calm the immune response. The drugs appear to protect laboratory-grown cells from coronavirus, but scientists are only beginning to test the drugs for this condition in human clinical trials. For now, the drugs are being prescribed at a higher dose and for a shorter period of time for COVID than for other conditions.

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The precise mechanism of plasmodicidal action of the drug is not known. While the drug can inhibit certain enzymes, its effect is believed to result, in part, from its interaction with DNA. It is highly effective as a suppressive agent in patients with vivax or malariae malaria, in terminating acute attacks, and significantly lengthening the interval between treatment and relapse. In patients with a susceptible strain of falciparum malaria, it abolishes the acute attack and effects complete cure of the infection. In vitro studies with trophozoites of Entamoeba histolytica have demonstrated https://wp.stolaf.edu that chloroquine also possesses amebicidal activity comparable to that of emetine. Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract.

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