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Subjects and methods. Six South African centres collected data which included acetylcholine receptor-antibody AChR-ab status, delay before diagnosis, MG Foundation of America grade at onset, maximum severity and severity at last visit, therapies, outcomes and complications. The median age at symptom onset was 7 years IQR 4 - Children with post-pubertal onset had more severe MG, but deaths were infrequent. There was no racial variation with respect to AChR-ab status, maximum severity, or use of immunosuppression. Younger children developed ocular MG https://www.onlinepharmaciescanada.com and older children generalised MG. Persistent ophthalmoplegia developing as a MG complication is not uncommon among juveniles of African genetic ancestry. A successful approach to the management of this complication that causes significant morbidity is, as yet, unclear. One centre has described racial differences in the outcome of generalised MG among South Africans, finding that severe treatment-resistant extra-ocular muscle EOM paresis or ophthalmoplegia occurred almost exclusively in subjects of African genetic ancestry. We present the data from subjects with juvenile MG collected from 6 academic centres throughout South Africa, report the frequency of the ophthalmoplegic complication in ocular and generalised MG and outcome in response to treatment.
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