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Gemfibrozil is used to reduce the risk of developing coronary heart disease CHD in patients with type IIb hyperlipoproteinemia without clinical evidence of CHD primary prevention who have an inadequate response to dietary management, weight loss, exercise, and drugs known to reduce low-density lipoprotein LDL -cholesterol and increase high-density lipoprotein HDL -cholesterol e. Although gemfibrozil has been used effectively in patients with types IIa and IIb hyperlipoproteinemia to decrease elevated total or LDL-cholesterol concentrations, the drug appears to be more effective in reducing the incidence of serious coronary events in patients with type IIb hyperlipoproteinemia who have elevations of both LDL-cholesterol and triglyceride concentrations. See Cautions: Precautions and Contraindications.
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Conversely, therapy with extended-release tablets may be substituted for conventional tablets at the same total daily dosage of conventional tablets; dosage subsequently should be adjusted according to glycemic response. In patients transferring from conventional tablets to an extended-release tablet preparation, glycemic control should be closely monitored and dosage adjustments made accordingly.
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