Furthermore, lithium has been proposed to exert its treatment effects through mechanisms associated with neuronal plasticity. After the anti-manic effects of lithium were discovered, lithium has been used for the treatment of bipolar disorder BD, in both the acute and maintenance phases of depression and mania for the last sixty or more years. Furthermore, the changes in BD diagnostic criteria throughout the years, and the appearance of newer agents such as valproate and atypical antipsychotics, may also have influenced the use of lithium. Lithium is now considered the treatment of choice for long-term prophylaxis of new episodes, regarded as the only substance that prevents both new depressive and new manic episodes. Also, lithium is the only drug with an established anti-suicidal efficacy in BD. Although the pathophysiology of BD has not been completely elucidated, a large body of literature indicates BD to be associated with significant neuroanatomical alterations. Such results of studies implicate, a compromised integrity of frontal—subcortical and prefrontal—limbic brain regions, in the pathophysiology of BD.
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Joachim (taken for 1 to 6 years) 15.03.2016
21 users found this comment helpful.
Lithium for the treatment of exaggerated emotions, excessive excitability, hypomania, mood changes with alternating periods of happiness and depression, aggressive and independent harm behavior, low white blood cell count as a result of cancer treatment and other conditions. Lithium compounds are commonly used as psychiatric drugs. Some lithium salts are used as mood-stabilizing drugs, primarily for the treatment of bipolar disorder; they play a role in the treatment of depression and especially mania, both acute and prolonged.
Bettina (taken for 3 to 7 years) 22.02.2016
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Some medications for depression also increase the brain chemical serotonin. Taking lithium along with these medications for depression might increase serotonin too much and cause serious side effects including heart problems, shivering, and anxiety. Do not take lithium if you are taking medications for depression.
Markus (taken for 3 to 7 years) 12.10.2017
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