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New maximum daily dose restrictions including in elderly patients, contraindications, and warnings. Citalopram, a racemic mixture of R and S citalopram, is a selective serotonin reuptake inhibitor SSRI indicated for the treatment of major depressive disorder, panic disorder, and obsessive compulsive disorder. Escitalopram is the S enantiomer of citalopram indicated for major depressive episodes, panic disorder with or without agoraphobia, social anxiety disorder social phobia, generalised anxiety disorder, and obsessive compulsive disorder. However, recent data have further defined this risk and have clarified that their effects on the QT interval are dose dependent. The maximum dose of both medicines has therefore been restricted in patients older than 65 years. The data for citalopram include double-blind placebo-controlled electrocardiogram ECG studies.
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