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Levothyroxine was first made in It may also be used to treat goiter via its ability to lower thyroid-stimulating hormone TSH, a hormone that is considered goiter-inducing. Levothyroxine is also used to treat subclinical hypothyroidism which is defined by an elevated TSH level and a normal-range free T 4 level without symptoms. Dosages vary according to the age groups and the individual condition of the person, body weight and compliance to the medication and diet. Poor compliance in taking the medicine is the most common cause of elevated TSH levels in people receiving appropriate doses of levothyroxine.
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Limitations: The analyses focused on continuously insured patients who were adherent to Synthroid for at least 6 months and results may not be generalizable. The reliance on claims data does not allow for clinical examination of hypothyroidism or inclusion of some factors that may be associated with outcomes. The analyses assume that all prescriptions filled are taken as prescribed.
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