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Anticonvulsant, Miscellaneous. Valproic acid inhibits lamotrigine glucuronidation. Whole tablets should be used for dosing, round calculated dose down to the nearest whole tablet. Alternatively, a suspension may be prepared using immediate release tablets see also Extemporaneous Prepared. The lamotrigine dosage should then be increased to mg daily while valproic acid is simultaneously decreased to mg daily; this dosage should be maintained for 1 week. Discontinuing valproic acid with current dose of lamotrigine mg daily: mg daily for week 1, then increase to mg daily beginning week 2.
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Walter (taken for 3 to 5 years) 24.09.2016
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Kurt (taken for 1 to 4 years) 25.01.2020
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