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Lamotrigine has emerged with a distinct place in the pharmacological treatment of bipolar disorder, with the potential to treat and prevent bipolar depression, which is the dominant and arguably most disabling and under-treated phase of the illness. However, this relative inadequacy compares favorably with the alternative treatment options for bipolar depression, which are marked by poor efficacy or risk of polarity switch. The designation of lamotrigine as first-line treatment for bipolar depression prophylaxis should be done in cognizance of this context, and it would seem prudent to await greater evidence of efficacy before designating lamotrigine as first-line treatment for other bipolar indications. Bipolar disorder has been estimated to have a population lifetime prevalence of between 0. The highly recurrent course of bipolar disorder Angst and Sellaro, its poor functional outcomes Mitchell et al and over-representation in the completed suicide population Rihmer and Kiss have been well-documented in the literature. In particular, more recent understanding of the natural course of bipolar disorder has highlighted its disease burden and challenged its historical conceptualization as an episodic illness with full inter-episode recovery Kraepelin

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This leaflet is about the use of lamotrigine to prevent epileptic seizures. This leaflet is for parents and carers about how to use this medicine in children. You will usually start by giving lamotrigine once a day, or every other day, while your child gets used to the medicine. This can be in the morning OR evening. When your child is used to lamotrigine, you will usually give it https://www.heb.com twice a day : once in the morning and once in the evening. Ideally, these times are 10—12 hours apart, for example sometime between 7am and 8 am and between 7pm and 8 pm.

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