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Serotonin syndrome may occur, particularly during combined use with SSRIs eg, fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, escitalopram or SNRIs eg, venlafaxine, duloxetine ; discontinue therapy if it occurs. Hypersensitivity reactions, including angioedema and anaphylaxis, reported; needle shield of prefilled syringe contains dry natural rubber a latex derivative that has potential to cause allergic reactions in latex-sensitive individuals. Data from a prospective pregnancy exposure registry and epidemiological studies of pregnant women have not detected increased frequency of birth defects or consistent pattern of birth defects among women exposed to sumatriptan compared with general population; in developmental toxicity studies in rats and rabbits, oral administration of sumatriptan to pregnant animals was associated with embryolethality, fetal abnormalities, and pup mortality; when administered by intravenous route to pregnant rabbits, sumatriptan was embryolethal.
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