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Bupropion hydrochloride is used in the treatment of major depressive disorder. Efficacy of conventional bupropion tablets for long-term use i. Efficacy of bupropion for the management of major depression has been established by a controlled study of approximately 6 weeks' duration in an outpatient setting and by 2 controlled studies of approximately 4 weeks' duration in inpatient settings. Patients received or mg daily of bupropion hydrochloride in the second study of 4 weeks' duration, which demonstrated efficacy only of the higher dosage, as indicated by improvement in total score on the HAM-D and in the CGI-S scale. However, in the study of 6 weeks' duration that evaluated the efficacy of mg daily of bupropion hydrochloride, the drug was superior to placebo in improvement of total score on the HAM-D, which was the primary measure of efficacy. In addition, depressed mood, as measured by item 1 on the HAM-D, was improved in patients treated with bupropion.

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