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Therefore, piroxicam is relatively contraindicated in patients with a history of or active GI disease including peptic ulcer disease, ulcerative colitis, or GI bleeding. Patients with a prior history of peptic ulcer disease or GI bleeding who use NSAIDs have a greater than fold increased risk for developing a GI bleed compared to patients with neither of these risk factors. Older patients seem to have a higher risk for GI ulceration or bleeding than younger adult patients; most fatal GI events occur in elderly or debilitated patients.
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