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Blakely has received consulting fees or honoraria from Merck, Amgen, and Wyeth. To compare the efficacy of doxycycline plus methotrexate MTX versus MTX alone in the treatment of early seropositive rheumatoid arthritis RA, and to attempt to differentiate the antibacterial and antimetalloproteinase effects of doxycycline. Treatment was started with an MTX dosage of 7. ACR50 responses were observed in MTX doses at 2 years were not different among groups. Further studies to evaluate the mechanism of action of tetracyclines in RA are indicated.
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Hugo (taken for 2 to 5 years) 17.10.2019
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DermNet provides Google Translate, a free machine translation service. Note that this may not provide an exact translation in all languages. Tetracyclines are oral antibiotics often used to treat skin diseases.
Manuel (taken for 1 to 6 years) 27.06.2019
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