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Development and validation of a dissolution test for diltiazem hydrochloride in immediate release capsules. This work describes the development and validation of a dissolution test for 60 mg of diltiazem hydrochloride in immediate release capsules. The best dissolution in vitro profile was achieved using potassium phosphate buffer at pH 6.
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Diltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. It has a molecular weight of
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