If you grew up as a teenager in the early s, you definitely remember Differin. It was the magical clear gel that your dermatologist prescribed to you to cure you of all your acne woes. And sure, there are lots of OTC retinols out there, but this one doesn't contain just any retinoid. According to Zeichner, after almost two decades of being prescription-only, the company that makes Differin applied to the FDA for approval to make the gel available OTC. While traditional acne-fighting OTC ingredients like salicylic acid and benzoyl peroxide are great, there's a reason dermatologists like Differin so much. A lot of products can be combined, and retinoids can be used alone but also in combination with other acne fighters, like benzoyl peroxide.
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