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Amlodipine is used alone or in combination with other classes of antihypertensive agents in the management of hypertension. Amlodipine in fixed combination with atorvastatin Caduet is used in patients for whom treatment with both amlodipine and atorvastatin is appropriate. Ultimately, choice of antihypertensive therapy should be individualized, considering the clinical characteristics of the patient e. Because many patients eventually will need drugs from 2 or more antihypertensive classes, experts generally state that the emphasis should be placed on achieving appropriate blood pressure control rather than on identifying a preferred drug to achieve that control. In the Antihypertensive and Lipid-lowering Treatment to Prevent Heart Attack Trial ALLHAT study, the long-term cardiovascular morbidity and mortality benefit of a long-acting dihydropyridine calcium-channel blocker amlodipine, a thiazide-like diuretic chlorthalidone, and an ACE inhibitor lisinopril were compared in a broad population of patients with hypertension at risk for coronary heart disease.
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