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Large clinical trials have confirmed the value of systemic adjuvant therapy in decreasing the risk of recurrence and death in patients with early breast cancer. However, the need to identify breast cancer patients who will benefit from adjuvant therapy, while sparing others from the side effects of futile treatment, is spurring research into predictive markers of chemotherapy sensitivity and resistance. In part this is because response is not directly observable. Data from large series of patients have demonstrated that preoperative neoadjuvant chemotherapy leads to significant reduction of tumor size downstaging and improves both the rate and the cosmetic results of breast- conserving surgery. In an early proof-of-principle pilot study of single agent neoadjuvant docetaxol, we identified a predictive gene expression pattern, and, using leave-one-cross validation, a method of internal validation, we demonstrated that the pattern was likely to accurately discriminate between responders and non-responders Chang, J.
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Other drugs may interact with cefpodoxime, so it is important to tell your veterinarian about any medications including vitamins, supplements, or herbal therapies that your pet is taking. Most overdoses of cefpodoxime cause diarrhea, vomiting, lack of appetite, and lethargy; however, some overdoses of cefpodoxime can be serious. Cloxacillin is given by mouth and is used off label to treat certain bacterial infections, most commonly staphylococcal infections.
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To recoup its profits, Merck has introduced another anticholesterol drug, Vytorin, which combines Zocor with Zetia, a medicine from Schering-Plough that is not a statin but also reduces cholesterol. Vytorin is about as effective as Lipitor at lowering cholesterol, so both Merck and have a stake in convincing doctors and insurers that they should pay extra for the increased potency their drugs offer over generic Zocor. But because Lipitor is so much more popular than Vytorin, has more to lose than Merck and Schering-Plough if generic simvastatin becomes a standard treatment.
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