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Other allopurinol-associated drug interactions are summarized in Table Although regimens for desensitization have been described, allopurinol should be avoided in patients with known allergies to allopurinol, including AHS. Robert Terkeltaub, in Rheumatology Sixth Edition, Because of primary renal clearance of oxypurinol, its half-life rises substantially in those with renal impairment.
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