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Progesterone P4 is a medication and naturally occurring steroid hormone. Progesterone is well tolerated and often produces few or no side effects. Progesterone is used in combination with an estrogen as a component of menopausal hormone therapy for the treatment of menopausal symptoms in peri- and postmenopausal women. The combination of an estrogen and oral progesterone has been found to improve bone mineral density BMD to a similar extent as an estrogen plus medroxyprogesterone acetate. In the French E3N-EPIC observational study, the risk of diabetes was significantly lower in women on menopausal hormone therapy, including with the combination of an oral or transdermal estrogen and oral progesterone or a progestin.
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