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Patients with an overactive bladder who were taking oxybutynin noticed a decrease in sweating, providing a rationale for studying the drug in people with hot flashes. Two prior studies in postmenopausal women who had refractory hot flashes reported decreases in symptoms when receiving full-dose oxybutynin.
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The drug depresses labyrinth excitability and vestibular stimulation, and it may affect the medullary chemoreceptor trigger zone. Similarly, Diconal is a combination drug containing dipipanone and cyclizine. The acetyl group is cleaved with diluted sulfuric acid.
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In normal postnatal development, many values normalize by 6 months of age, although changes can still be seen throughout childhood 3,4. Understanding the difference in neonatal values is imperative when interpreting coagulation studies to ensure the correct diagnosis of either a bleeding or clotting disorder.
It also has direct implications for the use of specific hemostatic interventions in a neonate i.
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