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Similar outcomes were found in the general medical practice setting, where the two treatments were similarly efficacious; except for a subgroup of patients not receiving benzodiazepines, the mean reduction in total MADRS scores favoured citalopram at 2, 4, 6 and 8 weeks. Two multicentre trials comparing citalopram with sertraline found both to be similarly effective in producing a meaningful reduction in total MADRS score, although one study found citalopram to be associated with anti-anxiety effects.
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