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The arguments over affordable life-saving medicines for the developing world intensified late last month when it was revealed that Glaxo-Wellcome has blocked the importation of inexpensive generic knock-offs of its premier AIDS drug, Combivir, into Ghana a small country in West Africa. As a result, the Indian company, Cipla Ltd. Miffed by this threat of generic importation, Glaxo officials now say they will make a similar offer to Ghana. The threat of generic competition made lift restrictions it wanted to impose on the fluconazole it is donating to South Africa. Initially the fluconazole was going to be provided for the treatment of cryptococcal meningitis only — and not for thrush — which affects more people. The pharmaceutical companies argue that without intellectual-property protection they would have no incentive to invest the millions required to discover and develop new drugs.
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From Combivir is a combination of lamivudine Epivir and zidovudine Retrovir, both components are active against the human immunodeficiency virus HIV and inhibit the activity of reverse transcriptase blocking the production of DNA and new viruses. Separately zidovudine and lamivudine may not be so effective as their combination which makes it more difficult for HIV to produce high resistant strains. Adults and children under 12 years of age should take Combivir once daily. Take the drug about the same time each day to avoid missing a dose. Food does not change absorption of the medication.
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