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The body does not get used to the medicine. ED tends to be a slowly progressive condition, increasing with age, however unless there is an underlying medical progression the same dose should produce the same effect.
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Benadryl may interact with monoamine oxidase inhibitors MAOIs, other over-the-counter cough, cold, allergy, or insomnia medications, anxiety or sleep medicines, antidepressants, or any other medications that make you feel drowsy, sleepy, or relaxed. Tell your doctor all medications and supplements you use. Benadryl has not been adequately evaluated in pregnant women.
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Tizanidine is a CYP1A2 substrate with a narrow therapeutic range. Emapalumab may normalize CYP activity, which may decrease the efficacy of drugs that are CYP substrates due to increased metabolism.
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