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Azathioprine and 6-mercaptopurine 6-MP are metabolized primarily by XO, hence co-administration of allopurinol leads to marked increases in circulating drug levels that can lead to bone marrow suppression. Other allopurinol-associated drug interactions are summarized in Table Although regimens for desensitization have been described, allopurinol should be avoided in patients with known allergies to allopurinol, including AHS.
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