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Do not coadminister with aliskiren in patients with diabetes mellitus or with renal impairment ie, GFR Use caution in congestive heart failure CHF, surgery or anesthesia, volume depletion consider lower dosage. Risk of hypotension, especially in patients with volume or salt depletion secondary to salt restriction or prolonged diuretic treatment; initiate treatment in such patients under close medical supervision and consider starting at a lower dose. Avoid use in patients with ascites resulting from cirrhosis or refractory ascites; monitor blood pressure and renal function closely if use cannot be avoided. Dual blockade of the renin-angiotensin system with angiotensin-receptor blockers ARBs, angiotensin-converting enzyme ACE inhibitors, or aliskiren is associated with increased risk of hypotension, hyperkalemia, and altered renal function including acute renal failure in comparison with monotherapy; closely monitor blood pressure. Children Can cause fetal harm when administered to a pregnant woman; use of drugs that act on renin-angiotensin system during second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents.
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Benicar olmesartan medoxomil is an angiotensin II receptor antagonist used to reduce and control hypertension high blood pressure. Generic Benicar is available outside of the U.
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- Hydrochlorothiazide is a thiazide diuretic water pill that helps prevent your body from absorbing too much salt, which can cause fluid retention.
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researchers sounded the first alarm regarding this suspicious connection between the drug and the gastrointestinal disease in June, a year before the agency took action. Beginning in, and for the next two years, Mayo researchers noted patients who presented with unusual gastrointestinal disease symptoms that mimicked similar side-effects to a different drug and which was also used to treat hypertension — which Benicar is designed to treat.
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Extracted June Use effective birth control to avoid pregnancy while you are taking Benicar. It has been approved for hypertension treatment in children and adolescents years old.
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FDA has approved changes to the labels of these drugs to include this concern. If patients taking olmesartan develop these symptoms and no other cause is found, the drug should be discontinued, and therapy with another antihypertensive started.
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